Epitope:

 

位置

 

TAP Peptide

MHC Peptide

CDS-3

 

43-52

HLA-B4403

PDEIFRSDTLY

DEIFRSDTLY

 

155-164

HLA-B5102

NAFNCTFEYI

NAFNCTFEYI

 

198-209

HLA-B5401, HLA-B0702, HLA-B51, HLA-B3501, HLA-B5301, HLA-Xw0401, HLA-A31, HLA-B7

KGYQPIDVVRDL

QPIDVVRDL

有一条不同

234-245

HLA-B5101 HLA-B5102

ILTAFSPAQDIW

TAFSPAQDIW

 

278-288

HLA-A31 HLA-A3 HLA-A6801 HLA-A11 HLA-A3301

CSQNPLAELKC

SQNPLAELK

 

297-315

HLA-A11 HLA-A6801 HLA-A3301 HLA-A68.1

KGIYQTSNFRVVPSGDVVR

GIYQTSNFR RVVPSGDVVR

 

336-356

HLA-B5102 HLA-B5101 HLA-A24 HLA-B51 HLA-Cw0301 HLA-A3

SVYAWERKKISNCVADYSVLY

 

 

365-382

HLA-Cw0401 HLA-A24 HLA-B0702 HLA-B3501 HLA-B5301 HLA-B51 HLA-A0201 HLA-A2

KCYGVSATKLNDLCFSNV

 

 

437-449

HLA-B14 HLA-B2705 HLA-A24

NYKYRYLRHGKLR

 

 

467-484

HLA-B5801 HLA-B3501 HLA-B5301 HLA-A24 HLA-B5401 HLA-B51

CTPPALNCYWPLNDYGFY

 

 

541-552

HLA-B2702

SSKRFQPFQQFG

KRFQPFQQFG

 

736-747

HLA-A3 HLA-A11 HLA-A31 HLA-A6801 HLA-A3301 HLA-B3902

LQYGSFCTQLNR

 

 

795-805

HLA-B2705 HLA-B2702

TKRSFIEDLLF

 

 

881-891

HLA-B5102

AMQMAYRFNGI

MAYRFNGI

 

884-893

HLA-B5103

MAYRFNGIGV

MAYRFNGIGV

 

1016-1027

HLA-B2705

LGQSKRVDFCGK

KRVDFCGK

 

1190-1206

HLA-A2 HLA-B5102 HLA-B5101 HLA-A0205

QYIKWPWYVWLGFIAGL

 

 

1215-1226

HLA-A24

LLCCMTSCCSCL

CMTSCCSCL

CDS-3目标中至少保留一个结果

372

TKLNDLCFSNV

2.5

KLNDLCFSNV

1896.3

743.7

HLA-A0201

1197

YVWLGFIAGL

3

YVWLGFIAGL

504

165.2

HLA-A0205

797

RSFIEDLLFNKV

2.2

FIEDLLFNKV

90

41.9

HLA-A1

736

LQYGSFCTQLNR

1.1

GSFCTQLNR

214.9

191.9

HLA-A11

38

RGVYYPDEIFR

1.2

GVYYPDEIFR

4.8

3.9

HLA-A1101

372

TKLNDLCFSNV

2.5

KLNDLCFSNV

1116.3

437.8

HLA-A2

365

KCYGVSATKL

0.7

CYGVSATKL

208.3

297.6

HLA-A24

439

KYRYLRHGKL

1.5

KYRYLRHGKL

440

283.9

HLA-A24

254

VGYLKPTTFML

1.2

GYLKPTTFML

300

260.9

HLA-A24

474

CYWPLNDYGFY

0.9

YWPLNDYGF

224.2

257.7

HLA-A24

1215

LLCCMTSCCSCL

1

CMTSCCSCL

210.7

210.7

HLA-A24

347

NCVADYSVLY

0.9

CVADYSVLY

210.8

229.1

HLA-A3

736

LQYGSFCTQLNR

1.1

GSFCTQLNR

237.6

212.1

HLA-A3

278

CSQNPLAELKC

0.6

SQNPLAELK

119.3

198.8

HLA-A3

278

CSQNPLAELKC

0.6

SQNPLAELK

128.1

213.5

HLA-A31

736

LQYGSFCTQLNR

1.1

GSFCTQLNR

213.2

190.4

HLA-A31

198

KGYQPIDVVR

0.8

GYQPIDVVR

126.4

164.2

HLA-A31

38

RGVYYPDEIFR

1.2

GVYYPDEIFR

12

9.8

HLA-A3101

736

LQYGSFCTQLNR

1.1

GSFCTQLNR

208.6

186.3

HLA-A3301

278

CSQNPLAELKC

0.6

SQNPLAELK

110.5

184.2

HLA-A3301

306

RVVPSGDVVR

2.2

RVVPSGDVVR

900

405.4

HLA-A68.1

553

RDVSDFTDSVR

3

DVSDFTDSVR

900

298

HLA-A68.1

198

KGYQPIDVVRDL

0.9

QPIDVVRDL

207.9

231

HLA-B0702

438

YKYRYLRHGKLR

2.3

YRYLRHGKLR

1000

431

HLA-B14

541

SSKRFQPFQQFG

4.4

KRFQPFQQFG

3000

681.8

HLA-B2702

796

KRSFIEDLLF

2

KRSFIEDLLF

600

292.7

HLA-B2702

795

TKRSFIEDLLF

2.2

KRSFIEDLLF

600

279.1

HLA-B2702

437

NYKYRYLRHGK

2.3

YRYLRHGK

10000

4347.8

HLA-B2705

438

YKYRYLRHGKLR

2.3

YRYLRHGKLR

10000

4310.3

HLA-B2705

1016

LGQSKRVDFCGK

1.5

KRVDFCGK

6000

4137.9

HLA-B2705

438

YKYRYLRHGK

3

YRYLRHGK

10000

3389.8

HLA-B2705

796

KRSFIEDLLF

2

KRSFIEDLLF

3000

1463.4

HLA-B2705

795

TKRSFIEDLLF

2.2

KRSFIEDLLF

3000

1395.3

HLA-B2705

198

KGYQPIDVVRDL

0.9

QPIDVVRDL

207

230

HLA-B3501

726

GDSTECANLL

5.1

GDSTECANLL

200

39.2

HLA-B3701

822

CLGDINARDLIC

6.2

GDINARDLIC

200

32

HLA-B3701

148

THTMIFDNAF

3.1

THTMIFDNAF

30

9.7

HLA-B3801

561

SVRDPKTSEIL

2.5

VRDPKTSEIL

45

18

HLA-B3901

30

YTQHTSSMRGVY

2.7

QHTSSMRGVY

45

16.5

HLA-B3901

735

LLQYGSFCTQL

1

LQYGSFCTQL

24

24

HLA-B3902

996

RAAEIRASANLA

4

AEIRASANLA

160

40.5

HLA-B40

44

DEIFRSDTLY

6.3

DEIFRSDTLY

2700

427.2

HLA-B4403

198

KGYQPIDVVRDL

0.9

QPIDVVRDL

207.1

230.1

HLA-B51

474

CYWPLNDYGFY

0.9

YWPLNDYGF

133.7

153.7

HLA-B51

365

KCYGVSATKL

0.7

CYGVSATKL

105.8

151.1

HLA-B51

417

MGCVLAWNTRNI

1.5

LAWNTRNI

572

381.3

HLA-B5101

336

SVYAWERKKI

2.5

YAWERKKI

2420

968

HLA-B5102

417

MGCVLAWNTRNI

1.5

LAWNTRNI

1210

806.7

HLA-B5102

1193

KWPWYVWLGFI

3.1

WPWYVWLGFI

2000

655.7

HLA-B5102

881

AMQMAYRFNGI

2

MAYRFNGI

1210

590.2

HLA-B5102

155

NAFNCTFEYI

2.9

NAFNCTFEYI

1464.1

504.9

HLA-B5102

234

ILTAFSPAQDIW

3.4

TAFSPAQDIW

1100

318.8

HLA-B5102

686

SIAYSNNTIAI

2

IAYSNNTIAI

363

181.5

HLA-B5103

884

MAYRFNGIGV

2.5

MAYRFNGIGV

363

148.2

HLA-B5103

489

IGYQPYRVVV

1.8

IGYQPYRVVV

375

208.3

HLA-B5201

487

TGIGYQPYRVVV

2.2

IGYQPYRVVV

375

174.4

HLA-B5201

198

KGYQPIDVVRDL

0.9

QPIDVVRDL

206.4

229.3

HLA-B5301

365

KCYGVSATKL

0.7

CYGVSATKL

106.8

152.6

HLA-B5301

474

CYWPLNDYGFY

0.9

YWPLNDYGF

127.2

146.2

HLA-B5301

198

KGYQPIDVVRDL

0.9

QPIDVVRDL

215.2

239.1

HLA-B5401

474

CYWPLNDYGFY

0.9

YWPLNDYGF

176.3

202.6

HLA-B5401

467

CTPPALNCYW

2.8

CTPPALNCYW

240

87.3

HLA-B5801

969

VEAEVQIDRL

2.3

VEAEVQIDRL

352

153

HLA-B60

1235

CCKFDEDDSEPV

1.2

DEDDSEPV

40

32

HLA-B61

899

YENQKQIANQF

4.5

NQKQIANQF

480

107.9

HLA-B62

198

KGYQPIDVVRDL

0.9

QPIDVVRDL

80

88.9

HLA-B7

831

LICAQKFNGL

1.1

ICAQKFNGL

16

14.5

HLA-B8

344

KISNCVADYSVL

2.3

NCVADYSVL

120

52.2

HLA-Cw0301

365

KCYGVSATKL

0.7

CYGVSATKL

220

314.3

HLA-Cw0401

198

KGYQPIDVVRDL

0.9

QPIDVVRDL

192

213.3

HLA-Cw0401

735

LLQYGSFCTQL

1

QYGSFCTQL

200

200

HLA-Cw0401

1206

LIAIVMVTIL

1.6

IAIVMVTIL

14.5

9.1

HLA-Cw0602

809

TLADAGFMKQY

1.7

ADAGFMKQY

64

38.3

HLA-Cw0702

CDS10

 

79-102

HLA-B51 HLA-B5401 HLA-B5301 HLA-B3501 HLA-B0702 HLA-B2705

SGPDDQIGYYRRATRRVRGGDGKM

 

 

103-114

HLA-B7 HLA-A3 HLA-B4403 HLA-B0702

KELSPRWYFYYL

 

 

121-131

HLA-B5102 HLA-B5101

SLPYGANKEGI

 

 

159-168

HLA-Cw0301 HLA-A24

VLQLPQGTTL

 

 

181-190

HLA-A6801 HLA-A31 HLA-A3 HLA-A3301 HLA-A11

SQASSRSSSR

QASSRSSSR

 

221-232

HLA-A0201

ALLLLDRLNQLE

LLLDRLNQLE

 

260-287

HLA-B2705 HLA-A3 HLA-A11 HLA-A31 HLA-A6801 HLA-A3301 HLA-A24 HLA-B51 HLA-B5301 HLA-B3501 HLA-B0702 HLA-B5401

RQKRTATKKQYNVTQAFGRRRGPEQTQGNF

 

 

304-322

HLA-A24 HLA-B5102

QIAQFAPSASAFFGMSRIG

 

CDS-11

 

13-24

HLA-B5101 HLA-B5102

LHLVDPQIQLTI

 

 

36-47

HLA-B5101 HLA-B0702 HLA-B5401 HLA-B51 HLA-B5301 HLA-B3501

NSADPKVYPIIL

DPKVYPIIL

 

51-77

HLA-A6801 HLA-A11 HLA-A3 HLA-A31 HLA-A3301 HLA-B2705 HLA-B5102 HLA-B5101

SQLSLSMARRNLDSLEARAFQSTPIV

 

CDS1

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

CDS-3位置以NC_004718为准,21477-25244

21706  GGC   GAC (AY278554) 第77aa

       Gly    Asp

22207 ATT   ACT (AY278554) 第244aa 在一预测epitope中间

       Ile   Thr

23205 GCT TCT(AY278554、AY278491) 第577aa

       Ala   Ser

中性小氨基酸在AY278554中都成了极性氨基酸。

                   21701                                        21750

 AY274119  (21686) TACTATTAATCATACGTTTGGCAACCCTGTCATACCTTTTAAGGATGGTA

 AY278491  (21701) TACTATTAATCATACGTTTGGCAACCCTGTCATACCTTTTAAGGATGGTA

 AY278554  (21676) TACTATTAATCATACGTTTGACAACCCTGTCATACCTTTTAAGGATGGTA

NC_004718  (21686) TACTATTAATCATACGTTTGGCAACCCTGTCATACCTTTTAAGGATGGTA

                  22201                                        22250

 AY274119  (22186) CCTTTTCACCTGCTCAAGACATTTGGGGCACGTCAGCTGCAGCCTATTTT

 AY278491  (22201) CCTTTTCACCTGCTCAAGACATTTGGGGCACGTCAGCTGCAGCCTATTTT

 AY278554  (22176) CCTTTTCACCTGCTCAAGACACTTGGGGCACGTCAGCTGCAGCCTATTTT

NC_004718  (22186) CCTTTTCACCTGCTCAAGACATTTGGGGCACGTCAGCTGCAGCCTATTTT

                   23201                                        23250

 AY274119  (23186) ATTAGACATTTCACCTTGCGCTTTTGGGGGTGTAAGTGTAATTACACCTG

 AY278491  (23201) ATTAGACATTTCACCTTGCTCTTTTGGGGGTGTAAGTGTAATTACACCTG

 AY278554  (23176) ATTAGACATTTCACCTTGCTCTTTTGGGGGTGTAAGTGTAATTACACCTG

NC_004718  (23186) ATTAGACATTTCACCTTGCGCTTTTGGGGGTGTAAGTGTAATTACACCTG