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Structural D/E-rich repeats play multiple roles especially in gene regulation through DNA/RNA mimicry. (2015) Molecular BioSystems
    (1246 reads)   _FPRINT
Reciprocal allosteric regulation of p38g and PTPN3 involves a PDZ domain–modulated complex formation. (2014) Science Signaling, IF=6.337 (中央研究院 生化所 王惠鈞院士)
 
使用者王惠鈞院士發表期刊論文,天門冬胺酸(Aspartic acid)與穀胺酸(Glutamic acid)與其他胺基酸相比,在某些蛋白質中常出現密集重複性,由於這些胺基酸帶負電,與DNA/RNA股線的磷酸基電性相同,可能參與RNA成熟時的相關流程與調節功能。這兩個胺基酸也可能影響蛋白質結合的專一性與嶼結合特性等。這項研究將可以提供藥物標靶上新的可能性。 
  

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