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DNA Demethylation Dynamics in the Human Prenatal Germline. (2015) Cell
    (1513 reads)   _FPRINT
DNA Demethylation Dynamics in the Human Prenatal Germline. (2015) Cell, IF=33.116 (中央研究院 植微所 陳柏仰研究員)
 
使用者陳柏仰研究員利用國網中心提供之次世代基因體分析平台,透過平台提供的bowtie2序列比對軟體,並撰寫統計分析程式,順利計算出胚胎內生殖細胞在母體子宮姙娠第50天到第137天的去甲基化的過程,瞭解全基因體去甲基化的時程、數量和位置。這個精密的去甲基化研究模式,正說明了個體的胚胎內生殖細胞之品質,早在第一代母體子宮內就已決定,以致影響到日後第三代的個體成年時的生殖能力。研究成果發表於頂尖期刊Cell上。(IF=33.116)
  

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